objective(s): repaglinide (rg) is an antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus. it has a good safety and efficacy profile in diabetic patients with complications in renal impairment and is an appropriate treatment choice, even for individuals with more severe degrees of renal malfunctions. the aim of the present study was to examine the protective...

resistance of the weanling rat to acetaminophen (ap ap)-induced hepatotoxicity is manifested with regard to a surge in apap-glutathione (osh) conjugate formation in the liver [allameh et al. mech aging dev 95(1997)71]. the present study was conducted to assess the role of this detoxification pathway in apapinduced lipid per6xidationin the liver. lipid peroxidation measured as thiobarbituric aci...

simultaneous exposure of highly-used chemical and physical agents are expected to happen in many occupations. in the present study the impact of simultaneous exposure to noise and formaldehyde on oxidative stress in blood and liver tissue of rat was investigated. animal study was conducted in the school of public health, shahid beheshti university of medical scineces, tehran, iran in 2013. a to...

3,4-methylenedioxymethamphetamine (mdma) or ecstasy, has had a widely spread popularity among young adults in recent years. kidney toxicity is one of the consequences of ecstasy. the studies have shown that ecstasy is metabolized by cytochrome p450 to reactive electrophil metabolites which detoxify by glutathione (gsh) conjugation. to our knowledge in vivo study of the effect of glutathione on ...

conclusions the observations suggest that simv may have a protective effect against cr(vi)-induced oxidative stress in the rat lung. background chromium is a naturally occurring heavy metal found in the environment. objectives the aim of the present study was to determine the effect of simvastatin (simv) on sodium dichromate [cr(vi)]-induced oxidative stress in the rat lung. materials and metho...

results the level of gsh significantly decreased. in contrast, the plasma level of mda significantly increased in a dose dependent manner in crvi-treated rats, when compared to control animals. simv had no effect on the biochemical parameters when compared to control rats, but significantly increased gsh concentration and decreased mda level in crvi-treated rats. materials and methods sixty-fou...

glutathione s-transferase (gst) is a superfamily enzyme which plays a major role indetoxification of xenobiotic compounds by catalyzing the conjugation of xenobiotic to cellular glutathione(gsh). gst-p is an important class of gsts which is expressed during the early stage of life and duringdevelopmental stages. its activity is relatively high during embryogenesis and immediately after birth an...

Many Vochysiaceae species are widely used in folk medicine to treat some diseases. Vochysia rufa, popularly known as “quina-doce”, has been type 1 and 2 diabetes mellitus the state of Minas Gerais, Brazil. Although antidiabetic antioxidant effects phytochemical profile rufa have already elucidated, further studies needed on this treatment specific tissues, such brain. This study investigated ef...

Objective(s): Bisphenol A (BPA), a xenoestrogenic endocrine disrupting agent, is widely used in the production of polycarbonate plastics and has potential adverse effects on the developing nervous system, memory and learning abilities. The protective effect of the crocin, an important active constituent in Crocus sativus L, on memory impairment induced by BPA in rat wa...